PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells

We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis. PI103 decreased the expression of MDR1 and MRP1, w...

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Detalles Bibliográficos
Autores principales: Marklein, Diana, Graab, Ulrike, Naumann, Ivonne, Yan, Tiandong, Ridzewski, Rosalie, Nitzki, Frauke, Rosenberger, Albert, Dittmann, Kai, Wienands, Jürgen, Wojnowski, Leszek, Fulda, Simone, Hahn, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534123/
https://www.ncbi.nlm.nih.gov/pubmed/23300809
http://dx.doi.org/10.1371/journal.pone.0052898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534123/
https://www.ncbi.nlm.nih.gov/pubmed/23300809
http://dx.doi.org/10.1371/journal.pone.0052898

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