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p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions
α-Synuclein is the main component of Lewy bodies, the intraneuronal inclusion bodies characteristic of Parkinson’s disease. Although α-synuclein accumulation is caused by inhibition of proteasome and autophagy-lysosome, the degradation of α-synuclein inclusions is still unknown. Formation of Lewy bo...
Autores principales: | Watanabe, Yoshihisa, Tatebe, Harutsugu, Taguchi, Katsutoshi, Endo, Yasuhisa, Tokuda, Takahiko, Mizuno, Toshiki, Nakagawa, Masanori, Tanaka, Masaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534125/ https://www.ncbi.nlm.nih.gov/pubmed/23300799 http://dx.doi.org/10.1371/journal.pone.0052868 |
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