Cargando…

Identification of Two Novel NPM1 Mutations in Patients with Acute Myeloid Leukemia

BACKGROUND: Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and up to 60% of patients with cytogenetically normal AML (CN-AML). METHODS: We performed mutational analysis, including...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeon, Yongbum, Seo, Sang Won, Park, Seonyang, Park, Seungman, Kim, So Yeon, Ra, Eun Kyung, Park, Sung Sup, Seong, Moon-Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Laboratory Medicine 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535198/ https://www.ncbi.nlm.nih.gov/pubmed/23301224 http://dx.doi.org/10.3343/alm.2013.33.1.60

Ejemplares similares

The First Study on Nucleotide-level Identification of Hb Koriyama in a Patient with Severe Hemolytic Anemia
por: Park, Seungman, et al.
Publicado: (2012)

Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A
por: Jo, Su Yeon, et al.
Publicado: (2016)

Acute Promyelocytic Leukemia or Acute Myeloid Leukemia with Mutated NPM1?
por: Cloobs-Venezia, Maximiliano, et al.
Publicado: (2022)

The frequency of NPM1 mutations in childhood acute myeloid leukemia
por: Braoudaki, Maria, et al.
Publicado: (2010)

Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia
por: Sun, Jiewen, et al.
Publicado: (2020)

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
por: Mariotti, Benedetta, et al.
Publicado: (2019)

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
por: Cocciardi, Sibylle, et al.
Publicado: (2019)

Identification of a novel NPM1 mutation in acute myeloid leukemia
por: Yao, Yiyi, et al.
Publicado: (2023)

Acute myeloid leukemia with concurrent NPM1 and RUNX1 mutations
por: Zuo, Zhuang, et al.
Publicado: (2023)

Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia
por: Forghieri, Fabio, et al.
Publicado: (2019)

Large Deletion in KCNQ1 Identified in a Family with Jervell and Lange-Nielsen Syndrome
por: Sung, Ji Yeon, et al.
Publicado: (2014)

Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1
por: Oñate, Guadalupe, et al.
Publicado: (2022)

NPM1 and FLT3-ITD/TKD Gene Mutations in Acute Myeloid Leukemia
por: Naseem, Shano, et al.
Publicado: (2021)

Minor BCR-ABL1-Positive Acute Myeloid Leukemia Associated With the NPM1 Mutation and FLT3 Internal Tandem Duplication
por: Kim, Moon Jung, et al.
Publicado: (2016)

Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia
por: Forghieri, Fabio, et al.
Publicado: (2021)

PB1880: ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 – A DIFFERENT ENTITY IN THE ELDERLY?
por: Gomes, Rita S, et al.
Publicado: (2023)

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)
por: Venanzi, Alessandra, et al.
Publicado: (2021)

The Impact of Mutation of Myelodysplasia-Related Genes in De Novo Acute Myeloid Leukemia Carrying NPM1 Mutation †
por: Wang, Yi, et al.
Publicado: (2022)

PB1894: NPM1 MUTATED ACUTE MYELOID LEUKEMIA: THE CO-MUTATION PATTERNS MAY BE ASSOCIATED WITH PROGNOSIS
por: Varelas, Christos, et al.
Publicado: (2023)

Identification of a GDF5 Mutation in a Korean Patient with Brachydactyly Type C without Foot Involvement
por: Seo, Soo Hyun, et al.
Publicado: (2013)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
por: Hirsch, Susanne, et al.
Publicado: (2017)

Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features
por: Chauhan, Pradeep Singh, et al.
Publicado: (2013)

Switch of the mutation type of the NPM1 gene in acute myeloid leukemia (AML): relapse or secondary AML?
por: Webersinke, G, et al.
Publicado: (2014)

Detection of minimal residual disease in NPM1-mutated acute myeloid leukemia by next-generation sequencing
por: Salipante, Stephen J., et al.
Publicado: (2014)

Prognostic Impact of Nucleophosmin 1 (NPM1) Gene Mutations in Egyptian Acute Myeloid Leukemia Patients
por: Zidan, Magda, et al.
Publicado: (2013)

Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations
por: Yang, Xinrui, et al.
Publicado: (2018)

Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival
por: Nagy, Ádám, et al.
Publicado: (2019)

NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia
por: Kuželová, Kateřina, et al.
Publicado: (2022)

NPM1 exon 5 mutations in acute myeloid leukemia: Implications in diagnosis and minimal residual monitoring
por: Wang, Peng, et al.
Publicado: (2022)

PB1792: NGS VS PCR FOR THE DETECTION OF NPM1 GENE MUTATIONS IN ACUTE MYELOID LEUKEMIA.
por: Severina, N., et al.
Publicado: (2022)

Genetic changes in refractory relapsed acute myeloid leukemia with NPM1 mutation: A case report
por: Wang, Shuang-Ling
Publicado: (2022)

Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia
por: Lisi, Véronique, et al.
Publicado: (2022)

Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML)
por: Djamai, Hanane, et al.
Publicado: (2021)

Colonic myeloid sarcoma with mutated NPM1 manifesting with ulceration
por: Tashakori, Mehrnoosh, et al.
Publicado: (2022)

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML
por: Diaz de la Guardia, Rafael, et al.
Publicado: (2020)

Isolated Mediastinal Myeloid Sarcoma after NPM1-Positive Pediatric Acute Myeloid Leukemia
por: Tüfekçi, Özlem, et al.
Publicado: (2019)

Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification
por: Eckardt, Jan-Niklas, et al.
Publicado: (2023)

Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia
por: Bailey, G. D., et al.
Publicado: (2020)

Examination of the FLT3 and NPM1 mutational status in patients with acute myeloid leukemia from southeastern Poland
por: Koczkodaj, Dorota, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_h7rc3bloml4t6620pgbm9l272p