T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

T-bet and GATA3 regulate the CD4+ T cell Th1/Th2 cell fate decision but little is known about the interplay between these factors outside of the murine Ifng and Il4/Il5/Il13 loci. Here we show that T-bet and GATA3 bind to multiple distal sites at immune regulatory genes in human effector T cells. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanhere, Aditi, Hertweck, Arnulf, Bhatia, Urvashi, Gökmen, M. Refik, Perucha, Esperanza, Jackson, Ian, Lord, Graham M., Jenner, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535338/
https://www.ncbi.nlm.nih.gov/pubmed/23232398
http://dx.doi.org/10.1038/ncomms2260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535338/
https://www.ncbi.nlm.nih.gov/pubmed/23232398
http://dx.doi.org/10.1038/ncomms2260

Ejemplares similares