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Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin

Neuroglobin (Ngb) is a globin present in the brain and retina of mammals. This hexacoordinated hemoprotein binds small diatomic molecules, albeit with lower affinity compared with other globins. Another distinctive feature of most mammalian Ngb is their ability to form an internal disulfide bridge t...

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Detalles Bibliográficos
Autores principales: Bocahut, Anthony, Derrien, Valérie, Bernad, Sophie, Sebban, Pierre, Sacquin-Mora, Sophie, Guittet, Eric, Lescop, Ewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535368/
https://www.ncbi.nlm.nih.gov/pubmed/23135388
http://dx.doi.org/10.1007/s00775-012-0956-2