Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents

Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 fo...

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Detalles Bibliográficos
Autores principales: Cao, Chun-Yan, Shen, Ying-Ying, Wang, Jian-Dong, Li, Li, Liang, Gao-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535584/
https://www.ncbi.nlm.nih.gov/pubmed/23289066
http://dx.doi.org/10.1038/srep01024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535584/
https://www.ncbi.nlm.nih.gov/pubmed/23289066
http://dx.doi.org/10.1038/srep01024

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