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Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153
A primary target for nicotine is the acetylcholine receptor channel (AChR). Some of the ability of nicotine to activate differentially AChR subtypes has been traced to a transmitter-binding site amino acid that is glycine in lower affinity and lysine in higher affinity AChRs. We studied the effects...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536520/ https://www.ncbi.nlm.nih.gov/pubmed/23277476 http://dx.doi.org/10.1085/jgp.201210896 |