Cargando…

Murine CD4(+)CD25(-) cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo

BACKGROUND: Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells demonstrate advantages over natural Treg (nTreg) cells in terms of increased number of starting population and greater potential to proli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Majowicz, Anna, van der Marel, Sander, te Velde, Anje A, Meijer, Sybren L, Petry, Harald, van Deventer, Sander J, Ferreira, Valerie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536706/ https://www.ncbi.nlm.nih.gov/pubmed/23198878 http://dx.doi.org/10.1186/1471-230X-12-172

Ejemplares similares

Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells
por: Lee, Jung Ho, et al.
Publicado: (2023)

The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin
por: Jia, Yu-Yan, et al.
Publicado: (2014)

PMA and Ionomycin Induce Glioblastoma Cell Death: Activation-Induced Cell-Death-Like Phenomena Occur in Glioma Cells
por: Han, Sheng, et al.
Publicado: (2013)

Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis
por: Duijvis, Nicolette W., et al.
Publicado: (2017)

Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response
por: Gao, Yu, et al.
Publicado: (2010)

Genome-wide immunity studies in the rabbit: transcriptome variations in peripheral blood mononuclear cells after in vitro stimulation by LPS or PMA-Ionomycin
por: Jacquier, Vincent, et al.
Publicado: (2015)

A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin
por: Zimmermann, Jakob, et al.
Publicado: (2015)

Effects of Dietary Plant Sterols and Stanol Esters with Low- and High-Fat Diets in Chronic and Acute Models for Experimental Colitis
por: te Velde, Anje A., et al.
Publicado: (2015)

Ionomycin Treatment Renders NK Cells Hyporesponsive
por: Romera-Cárdenas, Gema, et al.
Publicado: (2016)

Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4(+) T Lymphocytes
por: Tsai, Cheng-Chieh, et al.
Publicado: (2020)

Anti-Inflammatory Effects of Urocanic Acid Derivatives in Models Ex Vivo and In Vivo of Inflammatory Bowel Disease
por: Kammeyer, Arthur, et al.
Publicado: (2012)

Dynamics of Intermittent Delayed Emission in Single CdSe/CdS Quantum Dots
por: Hinterding, Stijn O. M., et al.
Publicado: (2020)

Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs
por: Majowicz, Anna, et al.
Publicado: (2019)

Effects of Ionomycin on Egg Activation and Early Development in Starfish
por: Vasilev, Filip, et al.
Publicado: (2012)

Intestinal CD11b(+) B Cells Ameliorate Colitis by Secreting Immunoglobulin A
por: Fu, Ying, et al.
Publicado: (2021)

Innate CD8αα(+) lymphocytes enhance anti‐CD40 antibody‐mediated colitis in mice
por: Kumar, Aaram A., et al.
Publicado: (2017)

Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
por: Zhou, Jun, et al.
Publicado: (2005)

Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells
por: Zou, Ying, et al.
Publicado: (2015)

A role for CD47 in the development of experimental colitis mediated by SIRPα(+)CD103(−) dendritic cells
por: Fortin, Genevieve, et al.
Publicado: (2009)

Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100
por: Maczuga, Piotr, et al.
Publicado: (2012)

CD4:CD8 ratio in children with perinatally acquired HIV‐1 infection
por: Seers, T, et al.
Publicado: (2018)

Human Thymic CD10(+) PD-1(+) Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a(–) CD95(+) CD28(–) CCR7(–) Developmental Stage
por: Billiet, Lore, et al.
Publicado: (2020)

CD4 T Cells Treated with gp120 Acquire a CD45R0+/CD45RA+ Phenotype
por: Trushin, Sergey A, et al.
Publicado: (2009)

Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages
por: Hamers, Anouk A. J., et al.
Publicado: (2015)

Enriched CD45RA(−)CD62L(+) central memory T and decreased CD3(+)CD56(+) natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients
por: Iwamuro, Masaya, et al.
Publicado: (2022)

Tyrosine 402 Phosphorylation of Pyk2 Is Involved in Ionomycin-Induced Neurotransmitter Release
por: Zhang, Zhao, et al.
Publicado: (2014)

Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8(+)CD11c(+) cells
por: Zhao, Hai-Mei, et al.
Publicado: (2017)

CD44 Antibodies and Immune Thrombocytopenia in the Amelioration of Murine Inflammatory Arthritis
por: Mott, Patrick J., et al.
Publicado: (2013)

Biexciton Blinking in CdSe-Based Quantum Dots
por: Vonk, Sander J. W., et al.
Publicado: (2023)

CD73 promotes colitis-associated tumorigenesis in mice
por: Liu, Xuan-Hui, et al.
Publicado: (2020)

Here to Heal: Mucosal CD74 Signaling in Colitis
por: Hoffman, Jill M., et al.
Publicado: (2020)

Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
por: Heinsbroek, Sigrid EM, et al.
Publicado: (2012)

CD28(−) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men
por: Vuddamalay, Yirajen, et al.
Publicado: (2017)

Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(−)CD69(+) subset proliferation
por: Yang, Qi, et al.
Publicado: (2016)

Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca(2+) channel internalization in mesenchymal stem cells
por: Li, Bei, et al.
Publicado: (2020)

Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis
por: Kekilli, Murat, et al.
Publicado: (2013)

Cytomegalovirus Colitis in Primary Hypogammaglobulinemia With Normal CD4+ T Cells: Deficiency of CMV-Specific CD8+ T Cells
por: Agrawal, Sudhanshu, et al.
Publicado: (2019)

CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy
Publicado: (1992)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation
por: Okunuki, Yoko, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8os1ilthluatotr4qfv3qitkev