State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility to their bin...

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Detalles Bibliográficos
Autores principales: Rapedius, Markus, Schmidt, Matthias R., Sharma, Chetan, Stansfeld, Phillip J., Sansom, Mark S.P., Baukrowitz, Thomas, Tucker, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536734/
https://www.ncbi.nlm.nih.gov/pubmed/22991046
http://dx.doi.org/10.4161/chan.22153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536734/
https://www.ncbi.nlm.nih.gov/pubmed/22991046
http://dx.doi.org/10.4161/chan.22153

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