Alteration of Introns in a Hyaluronan Synthase 1 (HAS1) Minigene Convert Pre-Mrna Splicing to the Aberrant Pattern in Multiple Myeloma (MM): MM Patients Harbor Similar Changes

Aberrant pre-mRNA splice variants of hyaluronan synthase 1 (HAS1) have been identified in malignant cells from cancer patients. Bioinformatic analysis suggests that intronic sequence changes can underlie aberrant splicing. Deletions and mutations were introduced into HAS1 minigene constructs to iden...

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Detalles Bibliográficos
Autores principales: Kriangkum, Jitra, Warkinton, Amanda, Belch, Andrew R., Pilarski, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536762/
https://www.ncbi.nlm.nih.gov/pubmed/23301075
http://dx.doi.org/10.1371/journal.pone.0053469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536762/
https://www.ncbi.nlm.nih.gov/pubmed/23301075
http://dx.doi.org/10.1371/journal.pone.0053469

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