Tackling Obstacles for Gene Therapy Targeting Neurons: Disrupting Perineural Nets with Hyaluronidase Improves Transduction

Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce mature neurons. However, both in vivo, and in vitro, where preliminary characterisation of viral particles takes place, transduction of neuron...

Descripción completa

Detalles Bibliográficos
Autores principales: Wanisch, Klaus, Kovac, Stjepana, Schorge, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536767/
https://www.ncbi.nlm.nih.gov/pubmed/23301052
http://dx.doi.org/10.1371/journal.pone.0053269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536767/
https://www.ncbi.nlm.nih.gov/pubmed/23301052
http://dx.doi.org/10.1371/journal.pone.0053269

Ejemplares similares