Critical Roles of Myc-ODC Axis in the Cellular Transformation Induced by Myeloproliferative Neoplasm-Associated JAK2 V617F Mutant

The acquired mutation (V617F) of Janus kinase 2 (JAK2) is observed in the majority of patients with myeloproliferative neoplasms (MPNs). In the screening of genes whose expression was induced by JAK2 (V617F), we found the significant induction of c-Myc mRNA expression mediated by STAT5 activation. I...

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Detalles Bibliográficos
Autores principales: Funakoshi-Tago, Megumi, Sumi, Kazuya, Kasahara, Tadashi, Tago, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536786/
https://www.ncbi.nlm.nih.gov/pubmed/23300995
http://dx.doi.org/10.1371/journal.pone.0052844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536786/
https://www.ncbi.nlm.nih.gov/pubmed/23300995
http://dx.doi.org/10.1371/journal.pone.0052844

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