Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes

AIMS/HYPOTHESIS: Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another feature of type 2 diabetes, contributes to impa...

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Detalles Bibliográficos
Autores principales: Kang, Z. F., Deng, Y., Zhou, Y., Fan, R. R., Chan, J. C. N., Laybutt, D. R., Luzuriaga, J., Xu, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536946/
https://www.ncbi.nlm.nih.gov/pubmed/23188390
http://dx.doi.org/10.1007/s00125-012-2776-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536946/
https://www.ncbi.nlm.nih.gov/pubmed/23188390
http://dx.doi.org/10.1007/s00125-012-2776-x

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