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The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice

SUMMARY: A single injection of the cyclooxygenase-2 (COX-2) selective inhibitor NS-398 reduces bone’s osteogenic response to a single period of mechanical loading in female rats, while women taking COX-2 selective inhibitors do not have lower bone mass. We show that daily NS-398 injection does not i...

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Detalles Bibliográficos
Autores principales: Sugiyama, T., Meakin, L. B., Galea, G. L., Lanyon, L. E., Price, J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536947/
https://www.ncbi.nlm.nih.gov/pubmed/22349912
http://dx.doi.org/10.1007/s00198-012-1922-0