Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs

In utero exposure to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, causes neural tube, heart, and limb defects. Valpromide (VPD), the amide derivative of VPA, does not inhibit HDAC activity and is a weak teratogen in vivo. The detailed mechanism of action of VPA as a teratogen is not...

Descripción completa

Detalles Bibliográficos
Autores principales: Paradis, France-Hélène, Hales, Barbara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537135/
https://www.ncbi.nlm.nih.gov/pubmed/23042728
http://dx.doi.org/10.1093/toxsci/kfs292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537135/
https://www.ncbi.nlm.nih.gov/pubmed/23042728
http://dx.doi.org/10.1093/toxsci/kfs292

Ejemplares similares