Structural basis of ligand recognition in 5-HT(3) receptors

The 5-HT(3) receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize the agonist...

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Detalles Bibliográficos
Autores principales: Kesters, Divya, Thompson, Andrew J, Brams, Marijke, van Elk, René, Spurny, Radovan, Geitmann, Matthis, Villalgordo, Jose M, Guskov, Albert, Helena Danielson, U, Lummis, Sarah C R, Smit, August B, Ulens, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537142/
https://www.ncbi.nlm.nih.gov/pubmed/23196367
http://dx.doi.org/10.1038/embor.2012.189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537142/
https://www.ncbi.nlm.nih.gov/pubmed/23196367
http://dx.doi.org/10.1038/embor.2012.189

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