Kif14 Mutation Causes Severe Brain Malformation and Hypomyelination

We describe a novel spontaneous mouse mutant, laggard (lag), characterized by a flat head, motor impairment and growth retardation. The mutation is inherited as an autosomal recessive trait, and lag/lag mice suffer from cerebellar ataxia and die before weaning. lag/lag mice exhibit a dramatic reduct...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujikura, Kohei, Setsu, Tomiyoshi, Tanigaki, Kenji, Abe, Takaya, Kiyonari, Hiroshi, Terashima, Toshio, Sakisaka, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537622/
https://www.ncbi.nlm.nih.gov/pubmed/23308235
http://dx.doi.org/10.1371/journal.pone.0053490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537622/
https://www.ncbi.nlm.nih.gov/pubmed/23308235
http://dx.doi.org/10.1371/journal.pone.0053490

Ejemplares similares