Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels

Ivabradine is a specific heart rate-reducing agent approved as a treatment of chronic stable angina. Its mode of action involves a selective and specific block of HCN channels, the molecular components of sinoatrial "funny" (f)-channels. Different studies suggest that the binding site of i...

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Detalles Bibliográficos
Autores principales: Bucchi, Annalisa, Baruscotti, Mirko, Nardini, Marco, Barbuti, Andrea, Micheloni, Stefano, Bolognesi, Martino, DiFrancesco, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537762/
https://www.ncbi.nlm.nih.gov/pubmed/23308150
http://dx.doi.org/10.1371/journal.pone.0053132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537762/
https://www.ncbi.nlm.nih.gov/pubmed/23308150
http://dx.doi.org/10.1371/journal.pone.0053132

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