HER2 Stabilizes EGFR and Itself by Altering Autophosphorylation Patterns in a Manner That Overcomes Regulatory Mechanisms and Promotes Proliferative and Transformation Signaling

One of the causes of breast cancer is overexpression of the human epidermal growth factor receptor 2 (HER2). Enhanced receptor autophosphorylation and resistance to activation-induced down regulation have been suggested as mechanisms for HER2-induced sustained signaling and cell transformation. Howe...

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Detalles Bibliográficos
Autores principales: Hartman, Zachary, Zhao, Hua, Agazie, Yehenew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538112/
https://www.ncbi.nlm.nih.gov/pubmed/23027125
http://dx.doi.org/10.1038/onc.2012.418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538112/
https://www.ncbi.nlm.nih.gov/pubmed/23027125
http://dx.doi.org/10.1038/onc.2012.418

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