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HER2 Stabilizes EGFR and Itself by Altering Autophosphorylation Patterns in a Manner That Overcomes Regulatory Mechanisms and Promotes Proliferative and Transformation Signaling
One of the causes of breast cancer is overexpression of the human epidermal growth factor receptor 2 (HER2). Enhanced receptor autophosphorylation and resistance to activation-induced down regulation have been suggested as mechanisms for HER2-induced sustained signaling and cell transformation. Howe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538112/ https://www.ncbi.nlm.nih.gov/pubmed/23027125 http://dx.doi.org/10.1038/onc.2012.418 |