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Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models

The identification of causative mutations in the (pro)granulin gene (GRN) has been a major breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated GRN mutations are leading to neurodegeneration through a “loss-of-function” mechanism, encouraging researchers to devel...

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Detalles Bibliográficos
Autores principales: Kleinberger, Gernot, Capell, Anja, Haass, Christian, Van Broeckhoven, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538123/
https://www.ncbi.nlm.nih.gov/pubmed/23239020
http://dx.doi.org/10.1007/s12035-012-8380-8