Common Variants of Drosophila melanogaster Cyp6d2 Cause Camptothecin Sensitivity and Synergize With Loss of Brca2

Many chemotherapeutic agents selectively target rapidly dividing cells, including cancer cells, by causing DNA damage that leads to genome instability and cell death. We used Drosophila melanogaster to study how mutations in key DNA repair genes affect an organism’s response to chemotherapeutic drug...

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Detalles Bibliográficos
Autores principales: Thomas, Adam M., Hui, Carrie, South, Adam, McVey, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538347/
https://www.ncbi.nlm.nih.gov/pubmed/23316441
http://dx.doi.org/10.1534/g3.112.003996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538347/
https://www.ncbi.nlm.nih.gov/pubmed/23316441
http://dx.doi.org/10.1534/g3.112.003996

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