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Common Variants of Drosophila melanogaster Cyp6d2 Cause Camptothecin Sensitivity and Synergize With Loss of Brca2
Many chemotherapeutic agents selectively target rapidly dividing cells, including cancer cells, by causing DNA damage that leads to genome instability and cell death. We used Drosophila melanogaster to study how mutations in key DNA repair genes affect an organism’s response to chemotherapeutic drug...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538347/ https://www.ncbi.nlm.nih.gov/pubmed/23316441 http://dx.doi.org/10.1534/g3.112.003996 |