Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells

The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, which compromises the cells’ ability to generate entirely iPSC-derived adult mice (“all-iPSC mice”). Here, we show that reprogramming in the presence of as...

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Detalles Bibliográficos
Autores principales: Stadtfeld, Matthias, Apostolou, Effie, Ferrari, Francesco, Choi, Jiho, Walsh, Ryan M., Chen, Taiping, Oi, Steen, Kim, Sang Yong, Bestor, Tim, Shioda, Toshi, Park, Peter J., Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538378/
https://www.ncbi.nlm.nih.gov/pubmed/22387999
http://dx.doi.org/10.1038/ng.1110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538378/
https://www.ncbi.nlm.nih.gov/pubmed/22387999
http://dx.doi.org/10.1038/ng.1110

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