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Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries
BACKGROUND: Src plays various roles in tumour progression, invasion, metastasis, angiogenesis and survival. It is one of the multiple targets of multi-target kinase inhibitors in clinical uses and trials for the treatment of leukemia and other cancers. These successes and appearances of drug resista...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538513/ https://www.ncbi.nlm.nih.gov/pubmed/23173901 http://dx.doi.org/10.1186/1752-153X-6-139 |