Multilocus Genotypes of Relevance for Drug Metabolizing Enzymes and Therapy with Thiopurines in Patients with Acute Lymphoblastic Leukemia

Multilocus genotypes have been shown to be of relevance for using pharmacogenomic principles to individualize drug therapy. As it relates to thiopurine therapy, genetic polymorphisms of TPMT are strongly associated with the pharmacokinetics and clinical effects of thiopurines (mercaptopurine and aza...

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Detalles Bibliográficos
Autores principales: Stocco, Gabriele, Franca, Raffaella, Verzegnassi, Federico, Londero, Margherita, Rabusin, Marco, Decorti, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538559/
https://www.ncbi.nlm.nih.gov/pubmed/23335936
http://dx.doi.org/10.3389/fgene.2012.00309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538559/
https://www.ncbi.nlm.nih.gov/pubmed/23335936
http://dx.doi.org/10.3389/fgene.2012.00309

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