Cargando…
What does a modified-Fibonacci dose-escalation actually correspond to?
BACKGROUND: In most phase I oncology trials, it is often stated that the dose increments follow a “modified-Fibonacci sequence”. This term, however, is vague. METHODS: To better characterize this sequence, we reviewed 81 phase I trials based on this concept. RESULTS: Out of 198 phase I oncology tria...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538691/ https://www.ncbi.nlm.nih.gov/pubmed/22824322 http://dx.doi.org/10.1186/1471-2288-12-103 |