Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease

BACKGROUND: Selective modulation of different Aβ products of an intramembrane protease γ-secretase, could be the most promising strategy for development of effective therapies for Alzheimer's disease. We describe how different drug-candidates can modulate γ-secretase activity in cells, by study...

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Detalles Bibliográficos
Autores principales: Svedružić, Željko M., Popović, Katarina, Šendula-Jengić, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538728/
https://www.ncbi.nlm.nih.gov/pubmed/23308095
http://dx.doi.org/10.1371/journal.pone.0050759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538728/
https://www.ncbi.nlm.nih.gov/pubmed/23308095
http://dx.doi.org/10.1371/journal.pone.0050759

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