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Mimicking p14ARF Phosphorylation Influences Its Ability to Restrain Cell Proliferation

The INK4a/ARF locus on the short arm of chromosome 9 is one of the most frequently altered loci in human cancer. It is generally accepted that ARF is involved in oncogenic checkpoint pathways by sensitizing incipient cancer cells to undergo growth arrest or apoptosis through both p53-dependent and i...

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Detalles Bibliográficos
Autores principales: Vivo, Maria, Ranieri, Michela, Sansone, Federica, Santoriello, Cristina, Calogero, Raffaele A., Calabrò, Viola, Pollice, Alessandra, La Mantia, Girolama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538741/
https://www.ncbi.nlm.nih.gov/pubmed/23308265
http://dx.doi.org/10.1371/journal.pone.0053631