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RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4
T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the thymus, the earliest thymic progenitors, called CD4(−)CD8(−) ‘double negative’ (DN) thymocytes, pass through a checkpoint termed “β-selection...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538756/ https://www.ncbi.nlm.nih.gov/pubmed/23308188 http://dx.doi.org/10.1371/journal.pone.0053300 |