Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is known, the effect of this drug on intracellular peptides has not been previously explored. A quantitative peptidomics technique was used to examin...

Descripción completa

Detalles Bibliográficos
Autores principales: Gelman, Julia S., Sironi, Juan, Berezniuk, Iryna, Dasgupta, Sayani, Castro, Leandro M., Gozzo, Fabio C., Ferro, Emer S., Fricker, Lloyd D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538785/
https://www.ncbi.nlm.nih.gov/pubmed/23308178
http://dx.doi.org/10.1371/journal.pone.0053263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538785/
https://www.ncbi.nlm.nih.gov/pubmed/23308178
http://dx.doi.org/10.1371/journal.pone.0053263

Ejemplares similares