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Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib
Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is known, the effect of this drug on intracellular peptides has not been previously explored. A quantitative peptidomics technique was used to examin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538785/ https://www.ncbi.nlm.nih.gov/pubmed/23308178 http://dx.doi.org/10.1371/journal.pone.0053263 |