Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function

The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the amyloid-β (Aβ) peptide, which contains the sequence Val-His-His-Gln in the vicinity of the clea...

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Detalles Bibliográficos
Autores principales: Kim, Tae-Kyung, Han, Hye-Eun, Kim, Hannah, Lee, Jung-Eun, Choi, Daehan, Park, Woo Jin, Han, Pyung-Lim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538981/
https://www.ncbi.nlm.nih.gov/pubmed/23172351
http://dx.doi.org/10.3858/emm.2012.44.12.082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538981/
https://www.ncbi.nlm.nih.gov/pubmed/23172351
http://dx.doi.org/10.3858/emm.2012.44.12.082

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