Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory

The NR2A:NR2B subunit ratio of the NMDA receptors is widely known to increase in the brain from postnatal development to sexual maturity and to aging, yet its impact on memory function remains speculative. We have generated forebrain-specific NR2A overexpression transgenic mice and show that these m...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Zhenzhong, Feng, Ruiben, Jacobs, Stephanie, Duan, Yanhong, Wang, Huimin, Cao, Xiaohua, Tsien, Joe Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539144/
https://www.ncbi.nlm.nih.gov/pubmed/23301157
http://dx.doi.org/10.1038/srep01036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539144/
https://www.ncbi.nlm.nih.gov/pubmed/23301157
http://dx.doi.org/10.1038/srep01036

Ejemplares similares