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Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting

Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin s...

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Autores principales: Takenami, Iukary, Finkmoore, Brook, Machado, Almério, Emodi, Krisztina, Riley, Lee W., Arruda, Sérgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539439/
https://www.ncbi.nlm.nih.gov/pubmed/23320165
http://dx.doi.org/10.1155/2012/757152
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author Takenami, Iukary
Finkmoore, Brook
Machado, Almério
Emodi, Krisztina
Riley, Lee W.
Arruda, Sérgio
author_facet Takenami, Iukary
Finkmoore, Brook
Machado, Almério
Emodi, Krisztina
Riley, Lee W.
Arruda, Sérgio
author_sort Takenami, Iukary
collection PubMed
description Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.
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spelling pubmed-35394392013-01-14 Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting Takenami, Iukary Finkmoore, Brook Machado, Almério Emodi, Krisztina Riley, Lee W. Arruda, Sérgio Pulm Med Clinical Study Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient. Hindawi Publishing Corporation 2012 2012-12-17 /pmc/articles/PMC3539439/ /pubmed/23320165 http://dx.doi.org/10.1155/2012/757152 Text en Copyright © 2012 Iukary Takenami et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Takenami, Iukary
Finkmoore, Brook
Machado, Almério
Emodi, Krisztina
Riley, Lee W.
Arruda, Sérgio
Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title_full Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title_fullStr Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title_full_unstemmed Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title_short Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
title_sort levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539439/
https://www.ncbi.nlm.nih.gov/pubmed/23320165
http://dx.doi.org/10.1155/2012/757152
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