Cargando…
Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin s...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539439/ https://www.ncbi.nlm.nih.gov/pubmed/23320165 http://dx.doi.org/10.1155/2012/757152 |
_version_ | 1782255086416691200 |
---|---|
author | Takenami, Iukary Finkmoore, Brook Machado, Almério Emodi, Krisztina Riley, Lee W. Arruda, Sérgio |
author_facet | Takenami, Iukary Finkmoore, Brook Machado, Almério Emodi, Krisztina Riley, Lee W. Arruda, Sérgio |
author_sort | Takenami, Iukary |
collection | PubMed |
description | Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient. |
format | Online Article Text |
id | pubmed-3539439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35394392013-01-14 Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting Takenami, Iukary Finkmoore, Brook Machado, Almério Emodi, Krisztina Riley, Lee W. Arruda, Sérgio Pulm Med Clinical Study Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient. Hindawi Publishing Corporation 2012 2012-12-17 /pmc/articles/PMC3539439/ /pubmed/23320165 http://dx.doi.org/10.1155/2012/757152 Text en Copyright © 2012 Iukary Takenami et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Takenami, Iukary Finkmoore, Brook Machado, Almério Emodi, Krisztina Riley, Lee W. Arruda, Sérgio Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title_full | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title_fullStr | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title_full_unstemmed | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title_short | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
title_sort | levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539439/ https://www.ncbi.nlm.nih.gov/pubmed/23320165 http://dx.doi.org/10.1155/2012/757152 |
work_keys_str_mv | AT takenamiiukary levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting AT finkmoorebrook levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting AT machadoalmerio levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting AT emodikrisztina levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting AT rileyleew levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting AT arrudasergio levelsofinterferongammaincreaseaftertreatmentforlatenttuberculosisinfectioninahightransmissionsetting |