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A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

Human mesenchymal stromal cells (hMSCs) represent an attractive cell source for clinic applications. Besides being multi-potent, recent clinical trials suggest that they secrete both trophic and immunomodulatory factors, allowing allogenic MSCs to be used in a wider variety of clinical situations. T...

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Detalles Bibliográficos
Autores principales: Alves, Hugo, Munoz-Najar, Ursula, De Wit, Jan, Renard, Auke J S, Hoeijmakers, Jan H J, Sedivy, John M, Van Blitterswijk, Clemens, De Boer, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539748/
https://www.ncbi.nlm.nih.gov/pubmed/19818093
http://dx.doi.org/10.1111/j.1582-4934.2009.00931.x