NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

BACKGROUND: Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 agonist, have an analgesia-like effect in rat models of...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamada, Toshihiko, Zuo, Daiying, Yamamoto, Tatsuo, Olszewski, Rafal T, Bzdega, Tomasz, Moffett, John R, Neale, Joseph H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539905/
https://www.ncbi.nlm.nih.gov/pubmed/22971334
http://dx.doi.org/10.1186/1744-8069-8-67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539905/
https://www.ncbi.nlm.nih.gov/pubmed/22971334
http://dx.doi.org/10.1186/1744-8069-8-67

Ejemplares similares