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NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

BACKGROUND: Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 agonist, have an analgesia-like effect in rat models of...

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Detalles Bibliográficos
Autores principales:	Yamada, Toshihiko, Zuo, Daiying, Yamamoto, Tatsuo, Olszewski, Rafal T, Bzdega, Tomasz, Moffett, John R, Neale, Joseph H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539905/ https://www.ncbi.nlm.nih.gov/pubmed/22971334 http://dx.doi.org/10.1186/1744-8069-8-67

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