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Construction and Characterization of an in-vivo Linear Covalently Closed DNA Vector Production System

BACKGROUND: While safer than their viral counterparts, conventional non-viral gene delivery DNA vectors offer a limited safety profile. They often result in the delivery of unwanted prokaryotic sequences, antibiotic resistance genes, and the bacterial origins of replication to the target, which may...

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Detalles Bibliográficos
Autores principales: Nafissi, Nafiseh, Slavcev, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540006/
https://www.ncbi.nlm.nih.gov/pubmed/23216697
http://dx.doi.org/10.1186/1475-2859-11-154