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Pain Facilitation Brain Regions Activated by Nalbuphine Are Revealed by Pharmacological fMRI
Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when co-administration with low dose naloxone. To examine the effect of nalbuphine or nalbup...
Autores principales: | Gear, Robert, Becerra, Lino, Upadhyay, Jaymin, Bishop, James, Wallin, Diana, Pendse, Gautam, Levine, Jon, Borsook, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540048/ https://www.ncbi.nlm.nih.gov/pubmed/23341872 http://dx.doi.org/10.1371/journal.pone.0050169 |
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