DNA Methyltransferase Inhibitor Zebularine Inhibits Human Hepatic Carcinoma Cells Proliferation and Induces Apoptosis

Hepatocellular carcinoma is one of the most common cancers worldwide. During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Zebularine (1-(β-(D)-ribofuranosyl)-1,2-dihydropyrimidin-2-one) acts as an inhibitor of D...

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Detalles Bibliográficos
Autores principales: Nakamura, Kazuaki, Aizawa, Kazuko, Nakabayashi, Kazuhiko, Kato, Natsuko, Yamauchi, Junji, Hata, Kenichiro, Tanoue, Akito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540068/
https://www.ncbi.nlm.nih.gov/pubmed/23320119
http://dx.doi.org/10.1371/journal.pone.0054036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540068/
https://www.ncbi.nlm.nih.gov/pubmed/23320119
http://dx.doi.org/10.1371/journal.pone.0054036

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