Vorinostat Induces Apoptosis and Differentiation in Myeloid Malignancies: Genetic and Molecular Mechanisms

BACKGROUND: Aberrant epigenetic patterns are central in the pathogenesis of haematopoietic diseases such as myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Vorinostat is a HDACi which has produced responses in these disorders. The purpose of this study was to address the functiona...

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Detalles Bibliográficos
Autores principales: Silva, Gabriela, Cardoso, Bruno A., Belo, Hélio, Almeida, António Medina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540071/
https://www.ncbi.nlm.nih.gov/pubmed/23320102
http://dx.doi.org/10.1371/journal.pone.0053766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540071/
https://www.ncbi.nlm.nih.gov/pubmed/23320102
http://dx.doi.org/10.1371/journal.pone.0053766

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