Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer’s Disease Pathophysiology

Transcription of DNA is essential for cell maintenance and survival; inappropriate localization of proteins that are involved in transcription would be catastrophic. In Alzheimer’s disease brains, and in vitro studies, we have found qualitative and quantitative deficits in transport into the nucleus...

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Detalles Bibliográficos
Autores principales: Mastroeni, Diego, Chouliaras, Leonidas, Grover, Andrew, Liang, Winnie S., Hauns, Kevin, Rogers, Joseph, Coleman, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540085/
https://www.ncbi.nlm.nih.gov/pubmed/23308199
http://dx.doi.org/10.1371/journal.pone.0053349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540085/
https://www.ncbi.nlm.nih.gov/pubmed/23308199
http://dx.doi.org/10.1371/journal.pone.0053349

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