Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer

Inactivation of the von Hippel-Lindau tumor suppressor (VHL) is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC), leading to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. He...

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Detalles Bibliográficos
Autores principales: Vanharanta, Sakari, Shu, Weiping, Brenet, Fabienne, Hakimi, A. Ari, Heguy, Adriana, Viale, Agnes, Reuter, Victor E., Hsieh, James J.-D., Scandura, Joseph M., Massagué, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540187/
https://www.ncbi.nlm.nih.gov/pubmed/23223005
http://dx.doi.org/10.1038/nm.3029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540187/
https://www.ncbi.nlm.nih.gov/pubmed/23223005
http://dx.doi.org/10.1038/nm.3029

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