Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity by which the lipidation of members of the LC3 family is facilitated. The crystal structure of the human ATG12~ATG5 conjugate bound to the amino-terminal region of ATG16L1, the factor that recruits the conjugate to autophagoso...

Descripción completa

Detalles Bibliográficos
Autores principales: Otomo, Chinatsu, Metlagel, Zoltan, Takaesu, Giichi, Otomo, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540207/
https://www.ncbi.nlm.nih.gov/pubmed/23202584
http://dx.doi.org/10.1038/nsmb.2431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540207/
https://www.ncbi.nlm.nih.gov/pubmed/23202584
http://dx.doi.org/10.1038/nsmb.2431

Ejemplares similares