Cargando…
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity by which the lipidation of members of the LC3 family is facilitated. The crystal structure of the human ATG12~ATG5 conjugate bound to the amino-terminal region of ATG16L1, the factor that recruits the conjugate to autophagoso...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540207/ https://www.ncbi.nlm.nih.gov/pubmed/23202584 http://dx.doi.org/10.1038/nsmb.2431 |