Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression

Dysregulation of ceramide synthesis has been associated with metabolic disorders such as atherosclerosis and diabetes. We examined the changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by knocking down serine pal mitoyltransferase subuni...

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Detalles Bibliográficos
Autores principales: Ruangsiriluk, Wanida, Grosskurth, Shaun E., Ziemek, Daniel, Kuhn, Max, des Etages, Shelley G., Francone, Omar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540863/
https://www.ncbi.nlm.nih.gov/pubmed/22628619
http://dx.doi.org/10.1194/jlr.M020941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540863/
https://www.ncbi.nlm.nih.gov/pubmed/22628619
http://dx.doi.org/10.1194/jlr.M020941

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