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Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds

BACKGROUND: Mouse limb bud is a prime model to study the regulatory interactions that control vertebrate organogenesis. Major aspects of limb bud development are controlled by feedback loops that define a self-regulatory signalling system. The SHH/GREM1/AER-FGF feedback loop forms the core of this s...

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Detalles Bibliográficos
Autores principales: Zuniga, Aimée, Laurent, Frédéric, Lopez-Rios, Javier, Klasen, Christian, Matt, Nicolas, Zeller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541112/
https://www.ncbi.nlm.nih.gov/pubmed/22888807
http://dx.doi.org/10.1186/1471-213X-12-23