Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model

BACKGROUND: Accumulation of extracellular matrix (ECM) and increased matrix metalloproteinase (MMP) activity are hallmarks of liver fibrosis. The aim of the present study was to develop a model of liver fibrosis combining ex vivo tissue culture of livers from CCl(4) treated animals with an ELISA det...

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Detalles Bibliográficos
Autores principales: Veidal, Sanne Skovgård, Nielsen, Mette Juul, Leeming, Diana Julie, Karsdal, Morten Asser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541216/
https://www.ncbi.nlm.nih.gov/pubmed/23249435
http://dx.doi.org/10.1186/1756-0500-5-686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541216/
https://www.ncbi.nlm.nih.gov/pubmed/23249435
http://dx.doi.org/10.1186/1756-0500-5-686

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