Functional Characterization of a Chimeric Soluble Fas Ligand Polymer with In Vivo Anti-Tumor Activity

Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inh...

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Detalles Bibliográficos
Autores principales: Daburon, Sophie, Devaud, Christel, Costet, Pierre, Morello, Aurore, Garrigue-Antar, Laure, Maillasson, Mike, Hargous, Nathalie, Lapaillerie, Delphine, Bonneu, Marc, Dechanet-Merville, Julie, Legembre, Patrick, Capone, Myriam, Moreau, Jean-François, Taupin, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541234/
https://www.ncbi.nlm.nih.gov/pubmed/23326557
http://dx.doi.org/10.1371/journal.pone.0054000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541234/
https://www.ncbi.nlm.nih.gov/pubmed/23326557
http://dx.doi.org/10.1371/journal.pone.0054000

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